Drug‐drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report

Summary What is known and objective Multi‐drug combinations often make chemotherapy difficult owing to drug‐drug interactions (DDIs). We report a rare and difficult‐to‐treat case due to DDIs between drugs for Mycobacterium avium complex (MAC) infection and antiepileptic drugs. Case description A 70‐...

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Published inJournal of clinical pharmacy and therapeutics Vol. 44; no. 1; pp. 119 - 121
Main Authors Yoshikawa, Naoki, Tazaki, Tomoya, Hatanaka, Mari, Oda, Yasuharu, Matsumoto, Nobuhiro, Sonoda, Junichiro, Ikeda, Ryuji
Format Journal Article
LanguageEnglish
Published England Hindawi Limited 01.02.2019
Subjects
Antiepileptic agents
Case reports
Chemotherapy
clarithromycin
Drugs
drug‐drug interaction
Epilepsy
Infections
Lung diseases
Phenobarbital
Phenytoin
rifampicin
therapeutic drug monitoring
rifampicin
clarithromycin
phenytoin
drug-drug interaction
therapeutic drug monitoring
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Summary:Summary What is known and objective Multi‐drug combinations often make chemotherapy difficult owing to drug‐drug interactions (DDIs). We report a rare and difficult‐to‐treat case due to DDIs between drugs for Mycobacterium avium complex (MAC) infection and antiepileptic drugs. Case description A 70‐year‐old Japanese woman was diagnosed as having pulmonary MAC disease. She had a history of symptomatic epilepsy, which was successfully treated with phenytoin and phenobarbital. Serum phenytoin concentrations increased upon the initiation of MAC infection treatment. What is new and Conclusion We evaluated DDIs and adjusted the dosage of drugs by monitoring the serum drug level.
ISSN:0269-4727
1365-2710
DOI:10.1111/jcpt.12764