Anomalous fetal venous return associated with major chromosomopathies in the late first trimester of pregnancy

We report three cases of increased nuchal translucency at 12–13 weeks of gestation in three fetuses with trisomies 13, 18 and 21. All three fetuses were associated with anomalous venous return evaluated by Doppler ultrasonography. Complete pathological examination was performed following termination...

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Published inUltrasound in obstetrics & gynecology Vol. 11; no. 3; pp. 209 - 213
Main Authors Matias, A., Montenegro, N., Areias, J. C., Brandão, O.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Science Ltd 01.03.1998
Subjects
Adult
Chromosome Aberrations - diagnostic imaging
Chromosome Disorders
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 18
Down Syndrome - diagnostic imaging
Female
Fetal Venous Return
Gestational Age
Humans
Increased Nuchal Translucency
Neck
Pregnancy
Trisomy
Trisomy 13
Trisomy 18
Trisomy 21
Ultrasonography, Doppler
Ultrasonography, Prenatal
Umbilical Arteries - diagnostic imaging
Umbilical Veins - diagnostic imaging
Vena Cava, Inferior - diagnostic imaging
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Summary:We report three cases of increased nuchal translucency at 12–13 weeks of gestation in three fetuses with trisomies 13, 18 and 21. All three fetuses were associated with anomalous venous return evaluated by Doppler ultrasonography. Complete pathological examination was performed following termination in each case. We suggest that alterations in the venous compartment can be an early sign of poor outcome and should prompt a detailed search for cardiac defects early in gestation. Copyright © 1998 International Society of Ultrasound in Obstetrics and Gynecology
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ISSN:0960-7692
1469-0705
DOI:10.1046/j.1469-0705.1998.11030209.x