Drug-Induced Autoimmune Hepatitis following Treatment with Zoledronic Acid

Adverse drug reactions are among the most frequent side effects of synthetic and complementary alternative drugs and represent the premier causes of license revocations and acute liver failure. Drug-induced liver injury can resemble literally any other genuine liver disease and usually responds well...

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Bibliographic Details
Published inCase reports in gastroenterology Vol. 11; no. 2; pp. 440 - 445
Main Authors Schneider, Jenny Sarah, Montani, Matteo, Stickel, Felix
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 08.08.2017
Karger Publishers
Subjects
Abdomen
Acids
Acute hepatitis
Adverse hepatic drug reactions
Antigens
Case reports
Drug-induced autoimmunity
Drug-induced liver injury
Enzymes
Family medical history
Gangrene
Hepatitis
Hepatology
Histology
Immunoglobulins
Immunosuppression
Irritable bowel syndrome
Liver
Osteoporosis
Pruritus
Single Case
United States > US
Switzerland
Adverse hepatic drug reactions
Drug-induced autoimmunity
Immunosuppression
Drug-induced liver injury
Acute hepatitis
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Summary:Adverse drug reactions are among the most frequent side effects of synthetic and complementary alternative drugs and represent the premier causes of license revocations and acute liver failure. Drug-induced liver injury can resemble literally any other genuine liver disease and usually responds well to drug dechallenge. However, in some cases autoimmune-like hepatitis can evolve, requiring short- and sometimes long-term immunosuppression. Here, we present the hitherto first case of autoimmune-like hepatitis following treatment with zoledronic acid.
ISSN:1662-0631
1662-0631
DOI:10.1159/000479314