High-resolution diffusion imaging with DIFRAD-FSE (Diffusion-Weighted Radial Acquisition of Data With Fast Spin-Echo) MRI

• Published in: Magnetic resonance in medicine Vol. 42; no. 1; pp. 11 - 18
• Main Authors: Trouard, Theodore P., Theilmann, Rebecca J., Altbach, Maria I., Gmitro, Arthur F.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.07.1999; Williams & Wilkins
• Subjects: Algorithms; Biological and medical sciences; Brain - pathology; Cerebrovascular Disorders - diagnosis; Diffusion; DIFRAD-FSE MRI; Equipment Design; Fourier Analysis; high-resolution; Humans; Image Enhancement - instrumentation; Image Processing, Computer-Assisted - instrumentation; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging - instrumentation; Medical sciences; Nervous system; RAD methods; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Sensitivity and Specificity; Human; Image quality; High resolution; Data acquisition; Central nervous system; Medical imagery; Spin echo; Technique; Diffusion; Nuclear magnetic resonance imaging; Image reconstruction; Brain (vertebrata)
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/(SICI)1522-2594(199907)42:1<11::AID-MRM3>3.0.CO;2-J

A novel MRI method, DIFRAD‐FSE (diffusion‐weighted radial acquisition of data with fast spin‐echo), is demonstrated that enables rapid, high‐resolution multi‐shot diffusion‐weighted MRI without significant artifacts due to motion. Following a diffusion‐weighting spin‐echo preparation period, multiple radial lines of Fourier data are acquired using spin‐echo refocusing. Images can be reconstructed from the radial data set using a magnitude‐only filtered back‐projection reconstruction algorithm that removes phase errors due to motion. Results from human brain imaging demonstrate the ability of DIFRAD‐FSE to acquire multiple radial lines of Fourier data each TR period without significant artifacts due to relaxation and to produce high‐resolution diffusion‐weighted MR images without significant artifacts from motion. Magn Reson Med 42:11–18, 1999. © 1999 Wiley‐Liss, Inc.