Anthropometrics, diet, and resting energy expenditure in Norwegian adults with achondroplasia

• Published in: American journal of medical genetics. Part A Vol. 179; no. 9; pp. 1745 - 1755
• Main Authors: Madsen, Andrea, Fredwall, Svein O., Maanum, Grethe, Henriksen, Christine, Slettahjell, Hanne B.
• Format: Journal Article
• Language: English; Norwegian
• Published: Hoboken, USA John Wiley & Sons, Inc 01.09.2019; Wiley Subscription Services, Inc
• Subjects: Achondroplasia; body composition; Body mass index; Body measurements; Calorimetry; Cardiovascular diseases; Diet; Energy balance; Energy expenditure; Energy intake; Obesity; resting energy expenditure; Risk factors; waist circumference; resting energy expenditure; achondroplasia; body composition; diet; waist circumference; body mass index
• ISSN: 1552-4825; 1552-4833
• DOI: 10.1002/ajmg.a.61272

Individuals with achondroplasia have a high prevalence of obesity and increased risk of cardiovascular disease. Fat distribution, diet, and caloric intake are known risk factors, but the literature concerning diet and energy balance in achondroplasia is limited. The main aim of this study was to describe the anthropometrics, diet, and resting energy expenditure (REE) in a Norwegian adult achondroplasia population. Here, we present a descriptive cross‐sectional study with the following variables: anthropometrics, the SmartDiet questionnaire, and dietary records. In addition, REE was measured and estimated using indirect calorimetry and prediction equations. A total of 33 adults with achondroplasia participated with a mean age of 40 years. Mean body mass index was 34.1 kg/m2, and mean waist circumference was 94.1 cm for men and 82.2 cm for women. Their diets were classified as unhealthy (38%) or in need of improvement (62%). The mean REE values for the total group were 21 kcal/kg for the male (n = 15) and 20 kcal/kg for the female (n = 18). This study revealed a high frequency of central obesity and unhealthy dietary habits in Norwegian adults with achondroplasia. Mean energy intake was low and only 10% higher than the mean REE, and does not explain the high prevalence of abdominal obesity in our population.