Novel and simple prognostic index for nasal natural killer/T-cell lymphoma

• Published in: Head & neck Vol. 36; no. 4; pp. 551 - 556
• Main Authors: Hanakawa, Hiroyuki, Orita, Yorihisa, Sato, Yasuharu, Takao, Soshi, Marunaka, Hidenori, Morishita, Tokiwa, Yamashita, Yasuhiko, Hori, Yasutaka, Domae, Shuhei, Inokuchi, Ikuo, Akagi, Seiko, Kondo, Eisei, Iwaki, Noriko, Motomiya, Kana, Okumura, Hirokazu, Yoshino, Tadashi, Nishizaki, Kazunori
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.04.2014; Wiley Subscription Services, Inc
• Subjects: blood examination; C-Reactive Protein - analysis; Female; Humans; L-Lactate Dehydrogenase - blood; local invasion; Lymphoma; Lymphoma, Extranodal NK-T-Cell - blood; Lymphoma, Extranodal NK-T-Cell - mortality; Male; Medical prognosis; Middle Aged; Nasal Cavity - pathology; nasal NK/T-cell lymphoma; Neoplasm Invasiveness; Nose Neoplasms - blood; Nose Neoplasms - mortality; Prognosis; prognostic index; Proportional Hazards Models; Receptors, Interleukin-2 - blood; Retrospective Studies; prognostic index; blood examination; local invasion; nasal NK/T-cell lymphoma; prognosis
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.23322

Background Few studies have investigated the prognostic factors for nasal natural killer (NK)/T‐cell lymphoma. Methods This was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T‐cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals. Results High serum levels of C‐reactive protein (≥1.0 mg/dL), lactate dehydrogenase (≥350 IU/L), and soluble interleukin‐2 receptor (sIL‐2R; ≥600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease‐specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2. Conclusion Our NPI is valid for anticipating prognosis of nasal NK/T‐cell lymphoma. © 2013 Wiley Periodicals, Inc. Head Neck 36: 551–556, 2014