Iron(III)-Catalyzed Cascade Reaction between Nitroolefins and 2-Aminopyridines: Synthesis of Imidazo[1,2-a]pyridines and Easy Access towards Zolimidine
The iron(III)‐catalyzed one‐pot cascade reaction between nitroolefins and 2‐aminopyridines has been demonstrated for the synthesis of imidazo[1,2‐a]pyridines by exploiting the bielectrophilic nature of nitroolefins. This methodology could be successfully applicable for the synthesis of zolimidine, a...
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Published in | Advanced synthesis & catalysis Vol. 355; no. 6; pp. 1065 - 1070 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
15.04.2013
WILEY‐VCH Verlag Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | The iron(III)‐catalyzed one‐pot cascade reaction between nitroolefins and 2‐aminopyridines has been demonstrated for the synthesis of imidazo[1,2‐a]pyridines by exploiting the bielectrophilic nature of nitroolefins. This methodology could be successfully applicable for the synthesis of zolimidine, a useful drug for the treatment of peptic ulcer. The reaction proceeds through Michael addition followed by intramolecular cyclization and in situ denitration. |
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Bibliography: | UGC istex:806F9593420F83CD4E2C6385CAF08DF8640EB4A2 DST, Govt. of India - No. SR/S5/GC-05/2010 CSIR ArticleID:ADSC201201112 UGC-SAP DST-FIST ark:/67375/WNG-D7H1GD3M-N ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.201201112 |