Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

The 3,3′‐disubstituted oxindole structural motif is a prominent feature in many alkaloid natural products, which include all kinds of tetrasubstituted carbon stereocenters, spirocyclic or not, all‐carbon or heteroatom‐containing. The catalytic asymmetric synthesis of the tetrasubstituted carbon ster...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 352; no. 9; pp. 1381 - 1407
Main Authors Zhou, Feng, Liu, Yun-Lin, Zhou, Jian
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.06.2010
WILEY‐VCH Verlag
Subjects
Alkaloids
asymmetric catalysis
Asymmetry
Bearing
bioactive compounds
Carbon
Catalysis
Catalysts
Natural products
oxindole framework
stereoselectivity
Synthesis
tetrasubstituted carbon stereocenters
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Summary:The 3,3′‐disubstituted oxindole structural motif is a prominent feature in many alkaloid natural products, which include all kinds of tetrasubstituted carbon stereocenters, spirocyclic or not, all‐carbon or heteroatom‐containing. The catalytic asymmetric synthesis of the tetrasubstituted carbon stereocenter at the C‐3 position of the oxindole framework integrates new synthetic methods and chiral catalysts, reflects the latest achievements in asymmetric catalysis, and facilitates the synthesis of sufficient quantities of related compounds as potential medicinal agents and biological probes. This review summarizes the recent progress in this area, and applications in the total synthesis of related bioactive compounds.
Bibliography:ark:/67375/WNG-73DB8JHL-2
East China Normal University
National Natural Science Foundation of China - No. 20902025
ArticleID:ADSC201000161
istex:878F7F25853711F1426AD2560B1D882A40B4A1D1
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1615-4150
1615-4169
1615-4169
DOI:10.1002/adsc.201000161