Fatal Anaphylactic Shock Ceftriaxone-Induced in a 4-Year-Old Child

One of the most used cephalosporin in clinical practice is ceftriaxone. Anaphylaxis due to the administration of ceftriaxone is considered a rare event. Here, we report a case of fatal anaphylactic shock after the administration of ceftriaxone in a child who had tolerated the drug in past exposures....

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Bibliographic Details
Published inPediatric emergency care Vol. 32; no. 1; p. 32
Main Authors Calapai, Gioacchino, Imbesi, Selene, Ventura-Spagnolo, Elvira, Cafeo, Viviana, Milone, Livio, Navarra, Michele, Gangemi, Sebastiano
Format Journal Article
LanguageEnglish
Published United States 01.01.2016
Subjects
Anaphylaxis - chemically induced
Anaphylaxis - diagnosis
Anaphylaxis - immunology
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - immunology
Autopsy - methods
Ceftriaxone - adverse effects
Ceftriaxone - immunology
Child, Preschool
Drug Hypersensitivity - etiology
Drug Hypersensitivity - immunology
Fatal Outcome
Humans
Male
Retrospective Studies
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Summary:One of the most used cephalosporin in clinical practice is ceftriaxone. Anaphylaxis due to the administration of ceftriaxone is considered a rare event. Here, we report a case of fatal anaphylactic shock after the administration of ceftriaxone in a child who had tolerated the drug in past exposures. The allergic pathogenesis is sustained by the clinical data (short time between the inoculation of the drug and the onset of the symptoms; past exposure to the same molecule and probable sensitization) and the postmortem examination findings (polivisceral congestion and intense eosinophilia found in the histological examination).
ISSN:1535-1815
DOI:10.1097/PEC.0000000000000311