Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields

Human lymphoblastoid cells of normal origin and from genetic instability syndromes, i.e. Fanconi anemia (FA) group C and ataxia telangectasia, were continuously exposed to extremely low frequency magnetic field (ELF-MF). We report that ELF-MF, though not perturbing cell cycle progression, increases...

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Published inFEBS letters Vol. 487; no. 3; pp. 397 - 403
Main Authors Mangiacasale, Rosamaria, Tritarelli, Alessandra, Sciamanna, Ilaria, Cannone, Maria, Lavia, Patrizia, Barberis, Massimo C., Lorenzini, Rodolfo, Cundari, Enrico
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 05.01.2001
Subjects
Apoptosis
AT, ataxia telangectasia
Ataxia telangectasia
Ataxia Telangiectasia - genetics
Ataxia Telangiectasia - pathology
Cell Cycle
Cell Death
Cell Line
ELF-MF, extremely low frequency magnetic field
Extremely low frequency electromagnetic field
FA, Fanconi anemia
FACS, fluorescence-activated cell sorter
FANCC, Fanconi anemia complementation group C
Fanconi anemia
Fanconi Anemia - genetics
Fanconi Anemia - pathology
Humans
Lymphoblastoid cell
Lymphocytes - cytology
Magnetics - adverse effects
Microscopy, Electron
Mutation
Transfection
Fanconi anemia
AT, ataxia telangectasia
Extremely low frequency electromagnetic field
FACS, fluorescence-activated cell sorter
Cell cycle
FA, Fanconi anemia
FANCC, Fanconi anemia complementation group C
Lymphoblastoid cell
Ataxia telangectasia
ELF-MF, extremely low frequency magnetic field
Apoptosis
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Summary:Human lymphoblastoid cells of normal origin and from genetic instability syndromes, i.e. Fanconi anemia (FA) group C and ataxia telangectasia, were continuously exposed to extremely low frequency magnetic field (ELF-MF). We report that ELF-MF, though not perturbing cell cycle progression, increases the rate of cell death in normal cell lines. In contrast, cell death is not affected in cells from genetic instability syndromes; this reflects a specific failure of the apoptotic response. Reintroduction of complementation group C in FA cells re-established the apoptotic response to ELF-MF. Thus, genes implicated in genetic instability syndromes are relevant in modulating the response of cells to ELF-MF.
Bibliography:ObjectType-Article-1
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ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(00)02376-0