Pharmacokinetics of drug permeation through human skin

Based on sorption and permeation characteristics of scopolamine in human skin in vitro and drug elimination kinetics obtained from pharmacokinetic studies, a mathematical model was developed for estimating and optimizing the temporal pattern of scopolamine delivery from a transdermal therapeutic sys...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 67; no. 10; p. 1370
Main Authors Chandrasekaran, S K, Bayne, W, Shaw, J E
Format Journal Article
LanguageEnglish
Published United States 01.10.1978
Subjects
Administration, Oral
Humans
In Vitro Techniques
Infusions, Parenteral
Kinetics
Models, Biological
Permeability
Pharmaceutical Preparations - metabolism
Skin Absorption
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Summary:Based on sorption and permeation characteristics of scopolamine in human skin in vitro and drug elimination kinetics obtained from pharmacokinetic studies, a mathematical model was developed for estimating and optimizing the temporal pattern of scopolamine delivery from a transdermal therapeutic system through human skin in vivo. Experimentally measured scopolamine delivery in vivo conformed to this model.
ISSN:0022-3549
DOI:10.1002/jps.2600671010