Pharmacokinetics of drug permeation through human skin
Based on sorption and permeation characteristics of scopolamine in human skin in vitro and drug elimination kinetics obtained from pharmacokinetic studies, a mathematical model was developed for estimating and optimizing the temporal pattern of scopolamine delivery from a transdermal therapeutic sys...
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Published in | Journal of pharmaceutical sciences Vol. 67; no. 10; p. 1370 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
01.10.1978
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Subjects | |
Online Access | Get more information |
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Summary: | Based on sorption and permeation characteristics of scopolamine in human skin in vitro and drug elimination kinetics obtained from pharmacokinetic studies, a mathematical model was developed for estimating and optimizing the temporal pattern of scopolamine delivery from a transdermal therapeutic system through human skin in vivo. Experimentally measured scopolamine delivery in vivo conformed to this model. |
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ISSN: | 0022-3549 |
DOI: | 10.1002/jps.2600671010 |