Exploring the Validity of Valproic Acid Animal Model of Autism

The valproic acid (VPA) animal model of autism spectrum disorder (ASD) is one of the most widely used animal model in the field. Like any other disease models, it can't model the totality of the features seen in autism. Then, is it valid to model autism? This model demonstrates many of the stru...

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Bibliographic Details
Published inExperimental neurobiology Vol. 24; no. 4; pp. 285 - 300
Main Authors Mabunga, Darine Froy N, Gonzales, Edson Luck T, Kim, Ji-Woon, Kim, Ki Chan, Shin, Chan Young
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Society for Brain and Neural Science 01.12.2015
한국뇌신경과학회
Subjects
Review : Autism Spectrum Disorders
뇌과학
predictive validity
social communication deficit
construct validity
face validity
animal model
autism spectrum disorder
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Summary:The valproic acid (VPA) animal model of autism spectrum disorder (ASD) is one of the most widely used animal model in the field. Like any other disease models, it can't model the totality of the features seen in autism. Then, is it valid to model autism? This model demonstrates many of the structural and behavioral features that can be observed in individuals with autism. These similarities enable the model to define relevant pathways of developmental dysregulation resulting from environmental manipulation. The uncovering of these complex pathways resulted to the growing pool of potential therapeutic candidates addressing the core symptoms of ASD. Here, we summarize the validity points of VPA that may or may not qualify it as a valid animal model of ASD.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
G704-SER000009883.2015.24.4.006
ISSN:1226-2560
2093-8144
DOI:10.5607/en.2015.24.4.285