Multiple sequence alignments

Multiple sequence alignments are very widely used in all areas of DNA and protein sequence analysis. The main methods that are still in use are based on ‘progressive alignment’ and date from the mid to late 1980s. Recently, some dramatic improvements have been made to the methodology with respect ei...

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Bibliographic Details
Published inCurrent opinion in structural biology Vol. 15; no. 3; pp. 261 - 266
Main Authors Wallace, Iain M, Blackshields, Gordon, Higgins, Desmond G
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2005
Subjects
Algorithms
Amino Acid Sequence
Base Sequence
Computer Simulation
DNA - analysis
DNA - chemistry
DNA - classification
Models, Chemical
Models, Molecular
Molecular Conformation
Molecular Sequence Data
Proteins - analysis
Proteins - chemistry
Proteins - classification
Sequence Alignment - methods
Sequence Alignment - trends
Sequence Analysis - methods
Sequence Analysis - trends
Sequence Homology
Software
Structure-Activity Relationship
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Summary:Multiple sequence alignments are very widely used in all areas of DNA and protein sequence analysis. The main methods that are still in use are based on ‘progressive alignment’ and date from the mid to late 1980s. Recently, some dramatic improvements have been made to the methodology with respect either to speed and capacity to deal with large numbers of sequences or to accuracy. There have also been some practical advances concerning how to combine three-dimensional structural information with primary sequences to give more accurate alignments, when structures are available.
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ISSN:0959-440X
1879-033X
DOI:10.1016/j.sbi.2005.04.002