Proteasomes, caught in the act

Although energy-dependent protein destruction by the proteasome has been known for over 30 years, how this intricate molecular machine uses ATP to power protein degradation has remained very poorly understood. In a recently published paper, Ding et al. present a snapshot of the proteasome mid-cataly...

Full description

Saved in:
Bibliographic Details
Published inCell research Vol. 27; no. 3; pp. 307 - 308
Main Author Tomko, Jr, Robert J
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.03.2017
Subjects
Research Highlight
Online AccessGet full text

Cover

More Information
Summary:Although energy-dependent protein destruction by the proteasome has been known for over 30 years, how this intricate molecular machine uses ATP to power protein degradation has remained very poorly understood. In a recently published paper, Ding et al. present a snapshot of the proteasome mid-catalysis, yielding new and unexpected insights into the catalytic mechanism of this ATP- powered multisubunit machine.
Bibliography:Although energy-dependent protein destruction by the proteasome has been known for over 30 years, how this intricate molecular machine uses ATP to power protein degradation has remained very poorly understood. In a recently published paper, Ding et al. present a snapshot of the proteasome mid-catalysis, yielding new and unexpected insights into the catalytic mechanism of this ATP- powered multisubunit machine.
31-1568
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Commentary-1
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2017.22