Impacts of the COVID-19 Pandemic on the Mental Health and Motor Deficits in Cuban Patients with Cerebellar Ataxias

• Published in: Cerebellum (London, England) Vol. 20; no. 6; pp. 896 - 903
• Main Authors: González-Garcés, Yasmany, Domínguez-Barrios, Yennis, Zayas-Hernández, Arianna, Sigler-Villanueva, Aldo A., Canales-Ochoa, Nalia, Hernández Oliver, María O., Ramírez-Bautista, María B., Caballero-Laguna, Alberto, Arrufat-Pie, Eduardo, Carrillo-Rodes, Frank J., Medrano-Montero, Jacqueline, Rodríguez-Álvarez, Yanela, Gámez-Rodríguez, Osiel, Guerra-Rondón, Leonardo A., Aguilera-Batista, Osvaldo, Vazquez-Mojena, Yaimee, Rodríguez-Labrada, Roberto, Velázquez-Pérez, Luis
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2021; Springer Nature B.V
• Subjects: Adult; Aged; Anxiety; Anxiety - epidemiology; Ataxia; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Cerebellar Ataxia - complications; Cerebellar Ataxia - epidemiology; Cerebellar Ataxia - psychology; Cerebellum; Complications; Coronaviruses; COVID-19; COVID-19 - diagnosis; COVID-19 - epidemiology; COVID-19 - psychology; COVID-19 Nucleic Acid Testing; Cuba - epidemiology; Depression - epidemiology; Exercise; Female; Humans; Long-term effects; Male; Mental depression; Mental Health; Middle Aged; Neurobiology; Neurology; Neurosciences; Original; Original Article; Pandemics; Patients; Perception; Physical training; Quality of life; RNA, Viral; SARS-CoV-2 - genetics; SARS-CoV-2 - isolation & purification; Self image; Severe acute respiratory syndrome coronavirus 2; Cuba; COVID-19; SARS-CoV2; Pandemic; Cerebellar ataxias; Mental health
• ISSN: 1473-4222; 1473-4230
• DOI: 10.1007/s12311-021-01260-9

Although there are no convincing evidences of detrimental effect of SARS-CoV2 infection on the cerebellum, the COVID-19 pandemic could impact the life quality of patients with cerebellar ataxias, but few studies have addressed this concern. To assess the motor and mental health changes caused by the COVID-19 pandemics in Cuban patients with cerebellar ataxias, three hundred four patients with cerebellar ataxias and 167 healthy controls were interviewed for risks of exposure to COVID-19, and the self-perception of the pandemics’ impact on the disease progression and on the mental health. All subjects underwent the Hospital Anxiety and Depression Scale. The patients reported low exposition to SARS-CoV2 infection, but one case was confirmed with a mild COVID-19. Overall, depressive and anxiety symptoms were significantly and marginally increased in patients, respectively, with higher scores in cases with severe and moderate ataxia. Positive patient’s impression of psychopathological changes was associated to increased age, age at onset, and anxiety. Sixty-seven patients had a positive self-perception of ataxia progression, which was mainly influenced by higher anxiety scores but not by the adherence to at-home exercise programs. However, the practice of physical exercise was related with lower depression and anxiety scores, but this therapeutical effect was not significantly influenced by the disease stage. We demonstrated the negative effect of the COVID-19 pandemic on the mental and motor deficits in Cuban patients with cerebellar ataxias and the positive effect of the at-home physical exercise programs on their mental well-being. These findings give rationales to develop tele-medicine approaches to minimize these health impacts and to study the long-term effects of such sequelae and accordingly define their treatments.