Control of developmental timing in animals

The molecular mechanisms that time development are now being deciphered in various organisms, particularly in Caenorhabditis elegans. Key recent findings indicate that certain C. elegans timekeeping genes are conserved across phyla, and their developmental expression patterns indicate that a timing...

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Bibliographic Details
Published inNature reviews. Genetics Vol. 2; no. 9; pp. 690 - 701
Main Author Rougvie, Ann E
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.09.2001
Subjects
Animals
Biological Evolution
Caenorhabditis elegans
Caenorhabditis elegans - genetics
Caenorhabditis elegans - growth & development
Cell cycle
Cell division
Genes
let-7 gene
lin-29 gene
lin-4 gene
lin-41 gene
Mutation
Nematodes
Organisms
RNA, Helminth - physiology
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Summary:The molecular mechanisms that time development are now being deciphered in various organisms, particularly in Caenorhabditis elegans. Key recent findings indicate that certain C. elegans timekeeping genes are conserved across phyla, and their developmental expression patterns indicate that a timing function might also be conserved. Small regulatory RNAs have crucial roles in the timing mechanism, and the cellular machinery required for production of these RNAs intersects with that used to process double-stranded RNAs during RNA interference.
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ISSN:1471-0056
1471-0064
DOI:10.1038/35088566