Dose dependency of germanium-dioxide-induced nephrotoxicity in rats

The dose dependency of germanium dioxide(GeO2)-induced nephrotoxicity was investigated experimentally in rat groups orally treated with high (150 mg/kg/day), moderate (75 mg/kg/day), or low (37.5 mg/kg/day) doses of GeO2, and in an untreated group. Renal dysfunction, indicated by the increase of blo...

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Published inNephron (2015) Vol. 57; no. 3; p. 349
Main Authors Sanai, T, Onoyama, K, Osato, S, Motomura, K, Oochi, N, Oh, Y, Okuda, S, Takaichi, S, Fujishima, M
Format Journal Article
LanguageEnglish
Published Switzerland 1991
Subjects
Animals
Blood Urea Nitrogen
Creatinine - blood
Dose-Response Relationship, Drug
Female
Germanium - administration & dosage
Germanium - metabolism
Germanium - toxicity
Kidney - drug effects
Kidney - pathology
Kidney - physiopathology
Rats
Rats, Inbred Strains
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Summary:The dose dependency of germanium dioxide(GeO2)-induced nephrotoxicity was investigated experimentally in rat groups orally treated with high (150 mg/kg/day), moderate (75 mg/kg/day), or low (37.5 mg/kg/day) doses of GeO2, and in an untreated group. Renal dysfunction, indicated by the increase of blood urea nitrogen and the decrease of creatinine clearance, and systemic toxicity by weight loss, anemia, and hypoproteinemia were more apparent in rats treated with higher dose of GeO2. Urinalysis including daily urinary protein excretion did not reveal any abnormalities in any of the groups. Urinary excretion and renal-tissue content of Ge were significantly elevated in the group of the higher dose of GeO2. Light microscopically, vacuolar degeneration and depositions of granules positive for periodic acid-Schiff in distal tubules were predominant in the higher-dose group of GeO2. The present study demonstrates that GeO2-induced nephrotoxicity develops dose dependently.
ISSN:1660-8151
DOI:10.1159/000186286