Fibroblasts in cancer: Defining target structures for therapeutic intervention

The functional importance of the tumor stroma for cancer growth and progression is increasingly recognized, but has not resulted in notable therapeutic developments yet. Within the mesenchymal tumor microenvironment, cancer-associated fibroblasts take the center stage and fuel tumor progression in v...

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Published inBiochimica et biophysica acta. Reviews on cancer Vol. 1872; no. 1; pp. 111 - 121
Main Authors Boesch, Maximilian, Baty, Florent, Rumpold, Holger, Sopper, Sieghart, Wolf, Dominik, Brutsche, Martin H.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.08.2019
Subjects
Cancer
Cancer stem cell
Cancer treatment
Cancer-associated fibroblast
Fibroblastic stromal cell
Immunotherapy
Tumor microenvironment
Cancer-associated fibroblast
Tumor microenvironment
Cancer treatment
Cancer stem cell
CAF
ELS
EMT
ECM
CSC
Fibroblastic stromal cell
Immunotherapy
FRC
FSC
SLO
MSC
Cancer
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Summary:The functional importance of the tumor stroma for cancer growth and progression is increasingly recognized, but has not resulted in notable therapeutic developments yet. Within the mesenchymal tumor microenvironment, cancer-associated fibroblasts take the center stage and fuel tumor progression in various ways including malignant cell potentiation, immune regulation and fibrosis. However, recent studies have demonstrated pronounced heterogeneity of the fibroblastic tumor stroma, which comprises a plethora of individual cell subsets with varying phenotypes and functions, some of which suppress malignant growth through immune engagement or crosstalk with the tumor vasculature. This article summarizes the various levels at which the fibroblastic tumor stroma may impact cancer progression and highlights potential target structures for future therapeutic intervention(s).
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0304-419X
1879-2561
DOI:10.1016/j.bbcan.2019.06.003