Antihypotensive activity of 2-acetylamino-5,6-dihydro-4H-1,3-thiazine for an endotoxic shock model in rats

The high anti-hypotonic activity of the new NOS inhibitor 2-acetylamino-5,6-dihydro-4 H -1,3-thiazine hydro-bromide was demonstrated for an endotoxic shock model in rats.

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 46; no. 4; pp. 210 - 212
Main Authors Filimonova, M. V., Trofimova, T. P., Borisova, G. S., Mandrugin, A. A.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.07.2012
Springer
Subjects
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Radiology
Radiology, Medical
Septic shock
NO-synthase inhibitors
endotoxic shock
anti-hypotonic activity
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Summary:The high anti-hypotonic activity of the new NOS inhibitor 2-acetylamino-5,6-dihydro-4 H -1,3-thiazine hydro-bromide was demonstrated for an endotoxic shock model in rats.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-012-0763-7