Feeding regulation by oleoylethanolamide synthesized from dietary oleic acid

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 165; p. 102228
• Main Authors: Igarashi, Miki, Iwasa, Kensuke, Yoshikawa, Keisuke
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.02.2021
• Subjects: Feeding; Oleic acid; Oleoylethanolamide; Oleic acid; Oleoylethanolamide; Feeding
• ISSN: 0952-3278; 1532-2823
• DOI: 10.1016/j.plefa.2020.102228

•OEA, a well-known satiety factor, is produced during feeing in the proximal intestine.•Excess consumption of dietary fat reduces OEA levels in the gut of rodents.•The amount of oleic acid in the diet influence intestinal OEA levels as well as food intake in rodents under standard dietary fat condition. Oleoylethanolamide (OEA), a well-known satiety factor, is produced during feeding in the proximal intestine. Enterocytes sense oleic acid in dietary fat via CD36 and convert it to OEA through NAPE-PLD dependent or independent pathways. The satiety function of OEA is known to involve peroxisome proliferator-activated receptor type-α (PPAR-α). OEA stimulates afferent sensory fibers (possibly those of the vagus nerve) and provoke the recruitment of feeding-controlling circuits in the brain that use oxytocin and histamine as neurotransmitters for regulating satiety. Dysfunction of OEA synthesis by high-fat feeding might contribute to increased weight and obesity. Here, we describe the roles played by OEA in the regulation of energy metabolism and food intake by introducing our preliminary data regarding this lipid mediator, and we briefly outline the biosynthesis and deactivation of OEA.