Dietary bioactive peptides: Human studies

• Published in: Critical reviews in food science and nutrition Vol. 57; no. 2; pp. 335 - 343
• Main Authors: Bouglé, Dominique, Bouhallab, Saïd
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 22.01.2017; Taylor & Francis Ltd
• Subjects: Animals; Bioactive peptides; Blood pressure; Cancer; Dietary minerals; Dietary Proteins - adverse effects; Dietary Proteins - metabolism; Dietary Proteins - therapeutic use; Dietary Supplements - adverse effects; Digestion; Fermentation; Food and Nutrition; Food engineering; Food Handling; human; Humans; immunity; Life Sciences; Meat - adverse effects; Metabolism; Milk Proteins - adverse effects; Milk Proteins - metabolism; minerals; Models, Biological; Peptide Fragments - adverse effects; Peptide Fragments - metabolism; Peptide Fragments - therapeutic use; Peptides; Peptides - adverse effects; Peptides - metabolism; Peptides - therapeutic use; Protein Hydrolysates - adverse effects; Protein Hydrolysates - metabolism; Protein Hydrolysates - therapeutic use; Protein Stability; Reproducibility of Results; Seafood - adverse effects; blood pressure; minerals; cancer; metabolism; immunity; Bioactive peptides; human; peptide bioactif; nutrition; allégation nutrionnelle; santé; produit laitier
• ISSN: 1040-8398; 1549-7852
• DOI: 10.1080/10408398.2013.873766

Current opinion strongly links nutrition and health. Among nutrients, proteins, and peptides which are encrypted in their sequences and released during digestion could play a key role in improving health. These peptides have been claimed to be active on a wide spectrum of biological functions or diseases, including blood pressure and metabolic risk factors (coagulation, obesity, lipoprotein metabolism, and peroxidation), gut and neurological functions, immunity, cancer, dental health, and mineral metabolism. A majority of studies involved dairy peptides, but the properties of vegetal, animal, and sea products were also assessed. However, these allegations are mainly based on in vitro and experimental studies which are seldom confirmed in humans. This review focused on molecules which were tested in humans, and on the mechanisms explaining discrepancies between experimental and human studies.