Anti-parkinsonism, hypoglycemic and anti-microbial activities of new poly fused ring heterocyclic candidates

A new series of poly fused pyrazolothienopyrimidine derivatives (2–14) were synthesized and their anti-parkinsonism, hypoglycemic and anti-microbial activities were evaluated. Some of the newly synthesized compounds exhibited better pharmacological and biological activities than the reference contro...

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Published inInternational journal of biological macromolecules Vol. 57; pp. 165 - 173
Main Authors Al-Harbi, Naif O., Bahashwan, Saleh A., Fayed, Ahmed A., Aboonq, Moutasem S., Amr, Abd El-Galil E.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2013
Subjects
Animals
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
anti-infective properties
Anti-parkinsonism
Antiparkinson Agents - chemical synthesis
Antiparkinson Agents - chemistry
Antiparkinson Agents - pharmacology
Aspergillus fumigatus - growth & development
Bacteria - growth & development
Candida albicans - growth & development
chemical reactions
Heterocyclic candidates
Heterocyclic Compounds, 2-Ring - chemical synthesis
Heterocyclic Compounds, 2-Ring - chemistry
Heterocyclic Compounds, 2-Ring - pharmacology
Hypoglycemic Agents - chemical synthesis
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Hypoglycemic and anti-microbial activities
medicinal properties
Mice
Parkinson Disease, Secondary - chemically induced
Parkinson Disease, Secondary - drug therapy
Poly ring systems
pyrimidines
spectral analysis
Heterocyclic candidates
Hypoglycemic and anti-microbial activities
Poly ring systems
Anti-parkinsonism
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Summary:A new series of poly fused pyrazolothienopyrimidine derivatives (2–14) were synthesized and their anti-parkinsonism, hypoglycemic and anti-microbial activities were evaluated. Some of the newly synthesized compounds exhibited better pharmacological and biological activities than the reference controls with low concentrations. The structures of newly synthesized compounds were confirmed by chemical, elemental and spectroscopic evidences. The detailed synthesis, spectroscopic data, and pharmacological activities were reported.
Bibliography:http://dx.doi.org/10.1016/j.ijbiomac.2013.03.019
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2013.03.019