Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols

• Published in: Frontiers in integrative neuroscience Vol. 17; p. 1271005
• Main Authors: Carresi, Cristina, Cardamone, Antonio, Coppoletta, Anna Rita, Mollace, Annachiara, Musolino, Vincenzo, Gliozzi, Micaela, Mollace, Vincenzo
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 14.09.2023; Frontiers Media S.A
• Subjects: Alzheimer's disease; Animal cognition; Atherosclerosis; bergamot; Blood pressure; Brain; cerebral metabolites; Citrus fruits; Cognitive ability; Flavonoids; Hypertension; Metabolism; Metabolites; N-Acetylaspartate; Neurological diseases; Neuroscience; NMR; Normal distribution; Nuclear magnetic resonance; Oxidative stress; Polyphenols; Ratios; Salt; Software; Spectrum analysis; Substantia alba; Surgery; Thalamus; Variance analysis; Veins & arteries; United States > US; Italy
• ISSN: 1662-5145; 1662-5145
• DOI: 10.3389/fnint.2023.1271005

Cerebral metabolites are associated with different physiological and pathological processes in brain tissue. Among them, the concentrations of N -acetylaspartate (NAA) and choline-containing compounds (Cho) in the thalamic region are recognized and analyzed as important predictive markers of brain impairment. The relationship among hypertension, modulation of brain metabolite levels and cerebral diseases is of recent investigation, leaving many unanswered questions regarding the origin and consequences of the metabolic damage caused in grey and white matter during hypertension. Here we provide evidence for the influence of hypertension on NAA and Cho ratios in hypertensive rat thalamus and how the use of natural occurring compounds ameliorates the balance of thalamic metabolites.