Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation

• Published in: Evidence-based complementary and alternative medicine Vol. 2022; pp. 1 - 11
• Main Authors: Cai, Wei, Wu, Li-Ren, Zhang, Shui-Li
• Format: Journal Article
• Language: English
• Published: New York Hindawi 30.07.2022; John Wiley & Sons, Inc
• Subjects: Alveoli; Antiviral drugs; Cell activation; Chronic infection; Chronic obstructive pulmonary disease; Coronaviruses; Cough; Cytokines; Diarrhea; Drug dosages; Enzyme inhibitors; Flavonoids; Flow cytometry; Forkhead protein; Gastroenteritis; Gastrointestinal diseases; Infections; Inflammation; Influenza; Influenza A; Lung diseases; Macrophages; Medicinal plants; Mosla scabra; Obstructive lung disease; Plant extracts; Pneumonia; Protein-tyrosine kinase; Proteins; Pyroptosis; Respiratory syncytial virus; Respiratory tract diseases; Signal transduction; Viral infections; Viruses
• ISSN: 1741-427X; 1741-4288
• DOI: 10.1155/2022/1688826

The lower respiratory tract infection, induced by influenza virus, coronaviruses, and respiratory syncytial virus, remains a serious threat to human health that can cause a global pandemic. Thus, finding effective chemicals and therapeutic measures to advance the functional restoration of the respiratory tract after infection has been the emphasis of the studies on the subjects. Mosla scabra is a natural medicinal plant used for treating various lung and gastrointestinal diseases, including viral infection, cough, chronic obstructive pulmonary disease, acute gastroenteritis, and diarrhoea. In this study, the antiviral and anti-inflammatory effects of total lignans (MSTL) extracted from the plant were investigated in influenza A virus (IAV)-infected mice and RAW 264.7 macrophages. MSTL could not only protect the macrophages against IAV-induced pyroptosis but also could lighten the lung inflammation induced by IAV in vivo and in vitro. The network pharmacology analysis revealed that differentially expressed genes, mainly involving in EGFR tyrosine kinase inhibitor resistance, endocrine resistance, HIF-1 signaling pathway, C-type lectin receptor signaling pathway, and FOXO signaling pathway, contributed to the IAV-induced alveolar macrophage dysfunction. It indicated that MSTL enhanced the function of alveolar macrophages and improved IAV-induced lung injury in mice.