Gender Effects on Association of Serotonin Transporter Gene Polymorphism with Symptoms of Central Fatigue

• Published in: Bulletin of experimental biology and medicine Vol. 147; no. 4; pp. 462 - 465
• Main Authors: Maluchenko, N. V, Schegolkova, J. V, Kulikova, M. A, Timofeeva, M. A, Shlepcova, V. A, Sysoeva, O. V, Tonevitsky, A. G
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.04.2009; Springer US; Springer Nature B.V
• Subjects: Affect; Alleles; Analysis of Variance; Biomedical and Life Sciences; Biomedicine; Cell Biology; central fatigue; Experimental Genetics; Fatigue - genetics; Female; gender differences; Humans; Internal Medicine; Laboratory Medicine; Male; Mental Processes; Neuropsychological Tests; Pathology; polymorphism; Polymorphism, Genetic; Psychological Tests; Serotonin Plasma Membrane Transport Proteins - genetics; serotonin transporter; Sex Characteristics; Surveys and Questionnaires; Young Adult; polymorphism; serotonin transporter; gender differences; central fatigue
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-009-0559-2

In order to test the “serotonin” hypothesis of the genesis of central fatigue, we studied association between genotype and fatigue (3-hour mental workload consisting of information processing and logical task solution) using analysis of variance for different indices (well-being, activity, mood, mental fatigue index). It was concluded that young men with serotonin deficit (LL genotype) and girls with serotonin excess (S genotype) were less tolerant to long-lasting mental workload. Thus, we confirmed that the degree of central fatigue depends on the function of the serotonin system and revealed gender differences in adaptive capacities of carriers of different variants of serotonin transporter.