Association between sleep disturbance and nocturnal blood pressure profiles by a linear mixed model analysis: the Nagahama study

• Published in: Sleep medicine Vol. 61; pp. 104 - 109
• Main Authors: Matsumoto, Takeshi, Tabara, Yasuharu, Murase, Kimihiko, Setoh, Kazuya, Kawaguchi, Takahisa, Nagashima, Shunsuke, Kosugi, Shinji, Nakayama, Takeo, Wakamura, Tomoko, Hirai, Toyohiro, Matsuda, Fumihiko, Chin, Kazuo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2019
• Subjects: Nocturnal blood pressure; Sleep disordered breathing; Sleep disturbance; Sleep efficiency; Sleep fragmentation; Sleep disturbance; Sleep fragmentation; Nocturnal blood pressure; Sleep efficiency; Sleep disordered breathing
• ISSN: 1389-9457; 1878-5506
• DOI: 10.1016/j.sleep.2019.01.049

We aimed to analyze associations of sleep disturbance, including sleep disordered breathing, sleep fragmentation, and sleep efficiency, with abnormal nocturnal blood pressure (BP) profiles that may be risk factors for adverse cardiovascular outcomes. The study included 5854 community residents with 20,725 multi-day measurements. Sleep fragmentation and efficiency were evaluated using a wrist-worn activity monitor. Sleep disordered breathing was assessed using the 3% oxygen desaturation index corrected for actigraphy-determined sleep duration. A timer-equipped standard cuff-oscillometric device was used for home and sleep BP monitoring. Mean nocturnal systolic BP (SBP) change was −8.6 ± 9.7% (−11.1 ± 12.6 mmHg), and inter-day correlation coefficient of the nocturnal SBP change was 0.443. Results of a linear mixed model analysis using daily measured values identified lower sleep efficiency (coefficient = −0.130, p < 0.001) as a determinant for decreased nocturnal SBP dipping beyond the interday variations of these parameters. Number of nocturnal urinations was another strong determinant (coefficient = 1.191, p < 0.001), although the association of sleep efficiency was independent of nocturnal urination, awake SBP, and sleep disordered breathing (coefficient = −0.102, p < 0.001). Sleep efficiency was also independently associated with sleep SBP level (coefficient = −0.138, p < 0.001). Estimated differences in nocturnal SBP dipping and sleep SBP level as a function of the degree of sleep efficiency (less than 80%) reached 1.63% (1.09–2.17%) and 2.16 mmHg (1.49–2.82%), respectively. More attention should be paid to sleep efficiency as a factor in maintaining circadian BP rhythm. •Lower sleep efficiency was associated with decreased nocturnal blood pressure dip, a risk factor for cardiovascular outcomes.•The association was independent of nocturnal urination frequency, awake blood pressure, and sleep disordered breathing.•More attention should be paid to sleep efficiency, to maintain the circadian blood pressure rhythm.