A display and analysis platform for gut microbiomes of minority people and phenotypic data in China

• Published in: Scientific reports Vol. 13; no. 1; p. 14247
• Main Authors: Li, Jun, Wei, Chunxue, Zhou, Ting, Mo, Chunfen, Wang, Guanjun, He, Feng, Wang, Pengyu, Qin, Ling, Peng, Fujun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 30.08.2023; Nature Publishing Group UK; Nature Portfolio
• Subjects: Altitude; Body mass index; Digestive system; Digestive tract; Intestinal microflora; Intestine; Microbiomes; Minority & ethnic groups; Relative abundance
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-36754-5

Abstract The minority people panmicrobial community database (MPPCD website: http://mppmcdb.cloudna.cn/ ) is the first microbe-disease association database of Chinese ethnic minorities. To research the relationships between intestinal microbes and diseases/health in the ethnic minorities, we collected the microbes of the Han people for comparison. Based on the data, such as age, among the different ethnic groups of the different regions of Sichuan Province, MPPCD not only provided the gut microbial composition but also presented the relative abundance value at the phylum, class, order, family and genus levels in different groups. In addition, differential analysis was performed in different microbes in the two different groups, which contributed to exploring the difference in intestinal microbe structures between the two groups. Meanwhile, a series of related factors, including age, sex, body mass index, ethnicity, physical condition, and living altitude, were included in the MPPCD, with special focus on living altitude. To date, this is the first intestinal microbe database to introduce altitude features. In conclusion, we hope that MPPCD will serve as a fundamental research support for the relationship between human gut microbes and host health and disease, especially in ethnic minorities.