Age-related susceptibility to oxygen and glucose deprivation damage in rat hippocampal slices

• Published in: Brain research Vol. 1025; no. 1; pp. 226 - 230
• Main Authors: Siqueira, Ionara Rodrigues, Cimarosti, Helena, Fochesatto, Cíntia, Salbego, Christianne, Netto, Carlos Alexandre
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 29.10.2004; Amsterdam Elsevier; New York, NY
• Subjects: Aging; Aging - metabolism; Animals; Biological and medical sciences; Cell Hypoxia - physiology; Cell Survival - physiology; DCF; Glucose - deficiency; Hippocampal slice; Hippocampus - metabolism; In Vitro Techniques; LDH release; Male; Medical sciences; MTT; Neurology; Oxygen and glucose deprivation; Oxygen Consumption - physiology; Rats; Rats, Wistar; Susceptibility to ischemia; Vascular diseases and vascular malformations of the nervous system; Development and regeneration; Oxygen and glucose deprivation; DCF; Aging; Susceptibility to ischemia; Hippocampal slice; LDH release; MTT; Senescence; Rat; Cardiovascular disease; Glucose; Encephalon; Vascular disease; Ischemia; Cerebrovascular disease; Age; Release; Nervous system diseases; Rodentia; Cerebral disorder; Vertebrata; Experimental disease; Sensitivity; Mammalia; Animal; Central nervous system disease; Hippocampus
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2004.08.005

Aging is an important risk factor for stroke. We evaluated the effects of aging on cell susceptibility to oxygen and glucose deprivation (OGD) in slices of the hippocampus from Wistar rats aged 2, 11 and 24 months. Lactate dehydrogenase (LDH) released to the incubation media and free radical content were markedly increased in the 24-month group submitted to OGD. These results confirm that hippocampal tissue from old animals is more susceptible to ischemia–reoxygenation injury.