Relationship between KRAS mutation and diffusion weighted imaging in colorectal liver metastases; Preliminary study

• Published in: European journal of radiology Vol. 125; p. 108895
• Main Authors: Gültekin, Mehmet Ali, Türk, Hacı Mehmet, Beşiroğlu, Mehmet, Toprak, Hüseyin, Yurtsever, Ismail, Yilmaz, Temel Fatih, Sharifov, Rasul, Uysal, Ömer
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2020
• Subjects: Colorectal cancer; Diffusion weighted imaging; KRAS; Liver metastases; ADC; GLUT1; ROIs; Liver metastases; NCCN; ROC; Colorectal cancer; 18F-FDG; EGFR; AUC; CRLM; DWI; KRAS; Diffusion weighted imaging; PCR
• ISSN: 0720-048X; 1872-7727
• DOI: 10.1016/j.ejrad.2020.108895

•Analyzing KRAS mutation is essential for colorectal liver metastases.•DWI is widely used in the detection and follow-up of CRLM.•ADC values were significantly decreased in KRAS mutation positive group.•ADC values of the CRLM can be used for predicting the KRAS mutation status. We aimed to investigate whether there are any differences in apparent diffusion coefficient (ADC) values obtained from colorectal liver metastases (CRLM) according to Kirsten rat sarcoma (KRAS) gene mutation status. In this retrospective study, we included 22 patients with 65 liver metastases due to colorectal cancer and performed KRAS gene mutation tests. We divided the patients into two groups as KRAS mutation positive (+) (n:10, 30 lesions) and the wild-type group (n:12, 35 lesions). Mann-Whitney U test was used to compare ADC and ADC mean values of the two groups. In addition, we performed receiver-operating characteristic (ROC) analysis to discriminate the two groups in terms of their ADC and ADCmean values. The ADC and ADCmean values were found to be statistically significantly lower in the KRAS (+) group compared to the wild-type group. ROC curve analysis revealed a statistically significant difference in terms of ADC and ADCmean with area under the curve (AUC) values of 0.680 and 0.760, respectively. The cut-off values for ADC and ADCmean were 986 × 10−6 mm2/s and 823 × 10−6 mm2/s, respectively. In our study, the lower ADC and ADCmean values of CRLM are associated with presence of KRAS mutation. ADC and ADCmean values derived from liver metastases due to the colorectal cancer can be used to differentiate KRAS mutation status.