Transient focal neurological deficits during pregnancy in carriers of inherited thrombophilia

• Published in: Stroke (1970) Vol. 31; no. 4; pp. 892 - 895
• Main Authors: KUPFERMINC, M. J, YAIR, D, BORNSTEIN, N. M, LESSING, J. B, ELDOR, A
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.04.2000; American Heart Association, Inc
• Subjects: Adolescent; Adult; Biological and medical sciences; Diseases of mother, fetus and pregnancy; Factor V - analysis; Female; Gynecology. Andrology. Obstetrics; Heterozygote; Humans; Ischemic Attack, Transient - complications; Medical sciences; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors - genetics; Pregnancy; Pregnancy Complications; Pregnancy. Fetus. Placenta; Prothrombin - genetics; Thrombophilia - blood; Thrombophilia - complications; Thrombophilia - genetics; Tropical medicine; Human; Hypercoagulability; Nervous system diseases; Stroke; Pregnancy disorders; Cardiovascular disease; Hemopathy; Maternal diseases; Epidemiology; Transitory; Cerebral disorder; Genetic disease; Vascular disease; Ischemia; Central nervous system disease; Risk factor; Female; Neurological disorder; Coagulopathy; Cerebrovascular disease
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/01.STR.31.4.892

The aim of our study was to investigate the association of transient ischemic cerebrovascular events during pregnancy and inherited thrombophilias. The study group comprised previously healthy pregnant women who had their first ischemic event during pregnancy (n=12). The control group included 24 healthy women matched with the study women for age, ethnicity, and smoking status. All women were evaluated for factor V Leiden mutation, methylenetetrahydrofolate reductase C677T gene mutation, the G20210A mutation in the prothrombin gene, and deficiencies of plasma proteins C and S and antithrombin III. Inherited thrombophilia was detected in 83% of women with transient neurological manifestations compared with 17% of the control group (P<0.001). Transient cerebrovascular ischemic events during pregnancy are associated with a high rate of inherited thrombophilias. Pregnant women with focal neurological symptoms should be evaluated for thrombophilia.