Two new steroidal saponins isolated from Anemarrhena asphodeloides

Two new steroidal saponins, named timosaponin P (1) and timosaponin Q (2), were isolated from the rhizome parts of Anemarrhena asphodeloides Bunge using various chromatographic methods. Their structures and absolute configurations were elucidated by a combination of spectroscopic and spectrometric d...

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Published inChinese journal of natural medicines Vol. 15; no. 3; pp. 220 - 224
Main Authors SUN, Xing-Huan, ZHU, Fu-Tao, ZHANG, Yu-Wei, CHEN, Fang-Fang, YU, Yun, SONG, Ning-Ning, HUANG, Xue-Feng
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.03.2017
Subjects
Absolute configuration
Anemarrhena - chemistry
Anemarrhena asphodeloides
chromatography
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
ECD
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
nuclear magnetic resonance spectroscopy
Oriental traditional medicine
rhizomes
Saponins - chemistry
Saponins - isolation & purification
steroid saponins
Steroidal saponin
Steroids - chemistry
Steroids - isolation & purification
Timosaponin P
Timosaponin Q
Anemarrhena asphodeloides
Steroidal saponin
Timosaponin P
Timosaponin Q
ECD
Absolute configuration
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Summary:Two new steroidal saponins, named timosaponin P (1) and timosaponin Q (2), were isolated from the rhizome parts of Anemarrhena asphodeloides Bunge using various chromatographic methods. Their structures and absolute configurations were elucidated by a combination of spectroscopic and spectrometric data, including 1D, 2D NMR, HR-ESI-MS and ECD calculations, and this is the first time the absolute configuration of C-23 of steroidal saponin was confirmed by ECD calculations.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(17)30038-9