A case of congenital herpes simplex virus infection diagnosed at 8 months of age

We present the case of an 8-month-old boy with the repeated recurrence of vesicles from the time of birth and who subsequently manifested psychomotor developmental delay. We retrospectively diagnosed the patient with congenital herpes simplex virus (HSV) infection. Computed tomography showed multipl...

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Published inBrain & development (Tokyo. 1979) Vol. 42; no. 4; pp. 369 - 372
Main Authors Yamamoto, Shiho, Nagamori, Tsunehisa, Komatsu, Shigetsuna, Shirai, Masaru, Suzutani, Tatsuo, Oki, Junichi
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2020
Subjects
Congenital herpes simplex virus infection
Intrauterine infection
Magnetic resonance image
Neonate
Repetitive vesicles
Skin lesion
Suppressive therapy
White matter lesion
Neonate
Skin lesion
Intrauterine infection
Congenital herpes simplex virus infection
Suppressive therapy
Magnetic resonance image
Repetitive vesicles
White matter lesion
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Summary:We present the case of an 8-month-old boy with the repeated recurrence of vesicles from the time of birth and who subsequently manifested psychomotor developmental delay. We retrospectively diagnosed the patient with congenital herpes simplex virus (HSV) infection. Computed tomography showed multiple calcifications in the periventricular white matter and thalami. The bilateral deep white matter showed an abnormally high signal intensity on T2-weighted magnetic resonance imaging. The patient required consecutive, suppressive therapy with valacyclovir to prevent the repeated recurrence of vesicles. This case presented a milder phenotype of congenital HSV infection in comparison to previous reports, and highlights the importance of the careful examination for this disease when neonates present with skin lesions.
ISSN:0387-7604
1872-7131
DOI:10.1016/j.braindev.2020.01.003