Invasive mechanical ventilation using a bilevel PAP ST device in a healthy swine model

• Published in: Sleep & breathing Vol. 24; no. 4; pp. 1645 - 1652
• Main Authors: Foster, Brian E., Diaz-Abad, Montserrat, Hudson, Arlene J., Bedocs, Peter, Doll, Darius M., Lopez, Steven A., Mares, John, Hutzler, Justin, Robertson, Brian D.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2020; Springer Nature B.V
• Subjects: Anesthesia; Animal models; Animals; Coronaviruses; COVID-19; COVID-19 - therapy; Dentistry; Gas exchange; Internal Medicine; Mechanical ventilation; Medicine; Medicine & Public Health; Models, Animal; Neurology; Otorhinolaryngology; Oxygenation; Pandemics; Pediatrics; Pneumology/Respiratory System; Positive-Pressure Respiration - instrumentation; Respiration, Artificial - instrumentation; Respiratory Function Tests; Sleep; Sleep Breathing Physiology and Disorders • Original; Sleep Breathing Physiology and Disorders • Original Article; Swine; Ventilators; Ventilators; Bilevel positive airway pressure; Coronavirus; Continuous positive airway pressure; Animal; Mechanical; Respiratory mechanics; Models
• ISSN: 1520-9512; 1522-1709; 1522-1709
• DOI: 10.1007/s11325-020-02141-x

Purpose The Coronavirus Disease 2019 (COVID-19) pandemic may cause an acute shortage of ventilators. Standard noninvasive bilevel positive airway pressure devices with spontaneous and timed respirations (bilevel PAP ST) could provide invasive ventilation but evidence on their effectiveness in this capacity is limited. We sought to evaluate the ability of bilevel PAP ST to effect gas exchange via invasive ventilation in a healthy swine model. Methods Two single limb respiratory circuits with passive filtered exhalation were constructed and evaluated. Next, two bilevel PAP ST devices, designed for sleep laboratory and home use, were tested on an intubated healthy swine model using these circuits. These devices were compared to an anesthesia ventilator. Results We evaluated respiratory mechanics, minute ventilation, oxygenation, and presence of rebreathing for all of these devices. Both bilevel PAP ST devices were able to control the measured parameters. There were noted differences in performance between the two devices. Despite these differences, both devices provided effective invasive ventilation by controlling minute ventilation and providing adequate oxygenation in the animal model. Conclusions Commercially available bilevel PAP ST can provide invasive ventilation with a single limb respiratory circuit and in-line filters to control oxygenation and ventilation without significant rebreathing in a swine model. Further study is needed to evaluate safety and efficacy in clinical disease models. In the setting of a ventilator shortage during the COVID-19 pandemic, and in other resource-constrained situations, these devices may be considered as an effective alternative means for invasive ventilation.