Enteric nervous system as a target and source of SARS-CoV-2 and other viral infections
Coronavirus disease 2019 (COVID-19) has been demonstrated to affect several systems of the human body, including the gastrointestinal and nervous systems. The enteric nervous system (ENS) is a division of the autonomic nervous system that extends throughout the gut, regulates gastrointestinal functi...
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Published in | American journal of physiology: Gastrointestinal and liver physiology Vol. 325; no. 2; pp. G93 - G108 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Physiological Society
01.08.2023
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Series | Coronavirus Disease (COVID-19) and Digestive System |
Subjects | |
Online Access | Get full text |
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Summary: | Coronavirus disease 2019 (COVID-19) has been demonstrated to affect several systems of the human body, including the gastrointestinal and nervous systems. The enteric nervous system (ENS) is a division of the autonomic nervous system that extends throughout the gut, regulates gastrointestinal function, and is therefore involved in most gut dysfunctions, including those resulting from many viral infections. Growing evidence highlights enteric neural cells and microbiota as important players in gut inflammation and dysfunction. Furthermore, the ENS and gastrointestinal immune system work together establishing relevant neuroimmune interactions during both health and disease. In recent years, gut-driven processes have also been implicated as players in systemic inflammation and in the initiation and propagation of several central nervous system pathologies, which seem to be hallmarks of COVID-19. In this review, we aim to describe evidence of the gastrointestinal and ENS infection with a focus on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We discuss here viral-induced mechanisms, neuroplasticity, and neuroinflammation to call attention to the enteric neuroglial network as a nervous system with a sensitive and crucial position to be not only a target of the new coronavirus but also a way in and trigger of COVID-19-related symptoms. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 L. Valdetaro and B. Thomasi contributed equally to this work and share first authorship. |
ISSN: | 0193-1857 1522-1547 |
DOI: | 10.1152/ajpgi.00229.2022 |