Social buffering diminishes fear response but does not equal improved fear extinction

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 33; no. 8; pp. 5007 - 5024
• Main Authors: Gorkiewicz, Tomasz, Danielewski, Konrad, Andraka, Karolina, Kondrakiewicz, Kacper, Meyza, Ksenia, Kaminski, Jan, Knapska, Ewelina
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 04.04.2023
• Subjects: Amygdala - physiology; Cerebral Cortex - metabolism; Extinction, Psychological - physiology; Fear - physiology; Humans; Original; Prefrontal Cortex - physiology; post-traumatic stress disorders; prelimbic cortex; infralimbic cortex; anterior cingulate cortex; fear memory extinction
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhac395

Abstract Social support during exposure-based psychotherapy is believed to diminish fear and improve therapy outcomes. However, some clinical trials challenge that notion. Underlying mechanisms remain unknown, hindering the understanding of benefits and pitfalls of such approach. To study social buffering during fear extinction, we developed a behavioral model in which partner’s presence decreases response to fear-associated stimuli. To identify the neuronal background of this phenomenon, we combined behavioral testing with c-Fos mapping, optogenetics, and chemogenetics. We found that the presence of a partner during fear extinction training causes robust inhibition of freezing; the effect, however, disappears in subjects tested individually on the following day. It is accompanied by lowered activation of the prelimbic (PL) and anterior cingulate (ACC) but not infralimbic (IL) cortex. Accordingly, blocking of IL activity left social buffering intact. Similarly, inhibition of the ventral hippocampus–PL pathway, suppressing fear response after prolonged extinction training, did not diminish the effect. In contrast, inhibition of the ACC–central amygdala pathway, modulating social behavior, blocked social buffering. By reporting that social modulation of fear inhibition is transient and insensitive to manipulation of the fear extinction-related circuits, we show that the mechanisms underlying social buffering during extinction are different from those of individual extinction.