Experimental coccidioidomycosis in the immunosuppressed rat

C. immitis inoculated rats are known to develop infection restricted to lung whereas cyclophosphamide (CY) treatment leads to widespread dissemination with considerable mortality. In this study, an attempt was made to elucidate the mechanisms involved in such behaviour. With this aim, spleen cells w...

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Published inRevista do Instituto de Medicina Tropical de São Paulo Vol. 34; no. 4; pp. 303 - 307
Main Authors REMESAR, M. C, BLEJER, J. L, NEGRONI, R, NEJAMKIS, M. R
Format Journal Article
LanguageEnglish
Published São Paulo Instituto de Medicina Tropical de São Paulo 01.07.1992
Instituto de Medicina Tropical
Subjects
Animals
Biological and medical sciences
Chronic Disease
Coccidioidomycosis - immunology
Colony-Forming Units Assay
Experimental mycoses and models
Hypersensitivity, Delayed - immunology
Immunocompromised Host - immunology
Immunosuppression - methods
Infectious diseases
Killer Cells, Natural - immunology
Male
Medical sciences
Mycoses
Rats
Rats, Inbred BUF
Spleen - cytology
Spleen - immunology
Spleen - transplantation
T-Lymphocytes, Regulatory - immunology
TROPICAL MEDICINE
Infection
Vertebrata
Experimental disease
Mammalia
Mycosis
Rat
Coccidioidomycosis
Animal
Rodentia
Immune deficiency
Cyclophosphamide
Immunosuppression
Reactivation
T suppressor cells
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Summary:C. immitis inoculated rats are known to develop infection restricted to lung whereas cyclophosphamide (CY) treatment leads to widespread dissemination with considerable mortality. In this study, an attempt was made to elucidate the mechanisms involved in such behaviour. With this aim, spleen cells were transferred from infected CY-treated to infected untreated rats, achieving significant specific inhibition in footpad swelling to coccidioidin in recipients, attributable to a suppressor T cell subpopulation induced by greater fungal antigen concentration arising from widespread C. immitis dissemination in immunosuppressed animals. NK activity proved similar regardless of CY treatment. Lastly, chronically infected rats presented increased colony forming units count after several weekly doses of CY, as happens in immunosuppressed patients harbouring a previous infection.
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ISSN:0036-4665
1678-9946
1678-9946
0036-4665
DOI:10.1590/S0036-46651992000400006