Peripheral immunity is associated with the risk of incident dementia

Central immunity components especially microglia in dementia have been well studied and corresponding immunotherapy gradually caught the attention. However, few studies focused on peripheral immunity and dementia. To address the issue, we examined the longitudinal association between incident dement...

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Published inMolecular psychiatry Vol. 27; no. 4; pp. 1956 - 1962
Main Authors Zhang, Ya-Ru, Wang, Ji-Jing, Chen, Shu-Fen, Wang, Hui-Fu, Li, Yu-Zhu, Ou, Ya-Nan, Huang, Shu-Yi, Chen, Shi-Dong, Cheng, Wei, Feng, Jian-Feng, Dong, Qiang, Yu, Jin-Tai
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.04.2022
Nature Publishing Group
Subjects
631/378
692/699
Adaptive immunity
Behavioral Sciences
Biological Psychology
Dementia
Dementia disorders
Etiology
Immunotherapy
Innate immunity
Leukocytes (neutrophilic)
Lymphocytes
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Microglia
Monocytes
Neurosciences
Pharmacotherapy
Psychiatry
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Summary:Central immunity components especially microglia in dementia have been well studied and corresponding immunotherapy gradually caught the attention. However, few studies focused on peripheral immunity and dementia. To address the issue, we examined the longitudinal association between incident dementia and peripheral immunity markers encompassing immune cell counts, and their derived ratios including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and lymphocyte-to-monocyte ratio (LMR), utilizing data of 361,653 participants from the UK Biobank (UKB). During a median follow-up of 8.99 years, 4239 participants developed dementia. The results revealed that increased innate immunity markers were associated with higher dementia risk (per SD increment hazard ratio [HR]; 95% confidence interval [CI] 1.14; 1.09–1.19 for neutrophils, 1.16; 1.11–1.20 for NLR and 1.11; 1.07–1.16 for SII), while increased adaptive immunity markers were associated with lower dementia risk (0.93; 0.90–0.97 for lymphocytes and 0.94; 0.90-0.98 for LMR). Our study pinpoints the differential role of innate and adaptive immunity in dementia incidence, which may provide some new perspectives in etiology and therapy of dementia.
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ISSN:1359-4184
1476-5578
1476-5578
DOI:10.1038/s41380-022-01446-5