Inhibition of inflammatory responses by epitaondiol and other marine natural products

The marine metabolites pacifenol, stypotriol triacetate and epitaondiol were tested for their effects on a number of inflammatory responses. Epitaondiol exhibited a potent topical anti-inflammatory activity related to inhibition of leukocyte accumulation. The other compounds showed a lower potency,...

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Bibliographic Details
Published inLife sciences (1973) Vol. 57; no. 2; pp. PL25 - PL30
Main Authors Gil, B., Ferrándiz, M.L., Sanz, M.J., Terencio, M.C., Ubeda, A., Rovirosa, J., San-Martin, A., Alcaraz, M.J., Payá, M.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 1995
Subjects
Animals
anti-inflammatory
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Blood Platelets - drug effects
Blood Platelets - metabolism
Calcimycin - pharmacology
Cytochrome c Group - metabolism
Ear, External - drug effects
Edema - chemically induced
Edema - drug therapy
Humans
Inflammation - drug therapy
Inflammation - metabolism
Inflammation - pathology
Leukotriene B4 - metabolism
marine natural products
Mice
myeloperoridase
Neutrophils - drug effects
Neutrophils - metabolism
Oxidation-Reduction
phospholipase A 2
Phospholipases A - metabolism
Phospholipases A2
Sesquiterpenes - pharmacology
Steroids
Stimulation, Chemical
Superoxides - blood
Terpenes - pharmacology
Tetradecanoylphorbol Acetate - toxicity
Thromboxane B2 - metabolism
anti-inflammatory
myeloperoridase
marine natural products
phospholipase A 2
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Summary:The marine metabolites pacifenol, stypotriol triacetate and epitaondiol were tested for their effects on a number of inflammatory responses. Epitaondiol exhibited a potent topical anti-inflammatory activity related to inhibition of leukocyte accumulation. The other compounds showed a lower potency, similar to that of indomethacin. None of the compounds affected superoxide generation by human neutrophils but pacifenol effectively inhibited the degranulation response. This compound and epitaondiol decreased the release of eicosanoids with a higher potency on the cyclo-oxygenase pathway. Only epitaondiol inhibited human recombinant synovial phospholipase A 2 activity in a concentration-dependent manner.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(95)00260-D