Ischemic and hemorrhagic disturbances in cerebral circulation alter contractile responses of the rat middle cerebral artery

• Published in: Brain research Vol. 995; no. 1; pp. 145 - 149
• Main Authors: Fadyukova, Olga E., Storozhevykh, Tatiana P., Pinelis, Vsevolod G., Koshelev, Vladimir B.
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 02.01.2004; Amsterdam Elsevier; New York, NY
• Subjects: Animals; Brain Ischemia - complications; Brain Ischemia - pathology; Brain Ischemia - physiopathology; Cerebral hemorrhage; Cerebral Hemorrhage - complications; Cerebral Hemorrhage - pathology; Cerebral Hemorrhage - physiopathology; Cerebral ischemia; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-1 - metabolism; Endothelin-1 - pharmacology; Female; Male; Middle cerebral artery; Middle Cerebral Artery - drug effects; Middle Cerebral Artery - physiopathology; Muscle Contraction - drug effects; Muscle Contraction - physiology; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - physiology; Rats; Rats, Wistar; Serotonin; Serotonin - metabolism; Serotonin - pharmacology; Vasoconstriction - drug effects; Vasoconstriction - physiology; Disorders of the nervous system; Cerebral ischemia; Serotonin; Cerebral hemorrhage; Middle cerebral artery; Endothelin-1
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2003.09.062

In our study, we examined middle cerebral artery (MCA) contractile responses in two animal models. After hemorrhagic disturbances in rats of Krushinsky–Molodkina strain (KMRs) a decrease in contractile responses to serotonin (5-HT) was observed. During incomplete global cerebral ischemia, MCAs had increased responsiveness to endothelin-1 (ET-1), but reduced responsiveness to serotonin. These findings suggest that cerebral circulation disorders alter cerebrovascular function possibly leading to secondary disturbances in brain circulation.