Nephrotic syndrome co-existing with type 1 diabetes in a 12-year-old boy: Case report and literature review

Occurrence of early nephrotic syndrome in type 1 diabetes mellitus patients is extremely rare. Herein, we report the case of a 12-year-old boy who presented to our pediatric nephrology clinic with generalized edema. He had been diagnosed with type 1 diabetes mellitus at age 9 and had been treated wi...

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Bibliographic Details
Published inSAGE open medical case reports Vol. 7; p. 2050313X19827734
Main Authors Bawahab, Noor S, Safdar, Osama Y, Nagadi, Sarah A, Saeedi, Asalh T, Mohammed Hussain, Raghad W
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2019
Sage Publications Ltd
SAGE Publishing
Subjects
Case Report
Case reports
Diabetes
Edema
Health risk assessment
Kidney diseases
type 1 diabetes
prednisolone
Nephrotic syndrome
edema
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Summary:Occurrence of early nephrotic syndrome in type 1 diabetes mellitus patients is extremely rare. Herein, we report the case of a 12-year-old boy who presented to our pediatric nephrology clinic with generalized edema. He had been diagnosed with type 1 diabetes mellitus at age 9 and had been treated with regular insulin. Examinations revealed normal kidney function, hypoalbuminemia, proteinuria (4+), hyperlipidemia, and low protein-to-creatinine ratio. The patient was diagnosed with idiopathic nephrotic syndrome and was empirically administered prednisolone for 12 weeks. Subsequently, prednisolone was tapered over 10–12 weeks. The patient showed good response to treatment. In conclusion, co-existence of nephrotic syndrome and type 1 diabetes mellitus may suggest an immunological basis; therefore, further studies are needed to investigate the relationship between these two conditions.
ISSN:2050-313X
2050-313X
DOI:10.1177/2050313X19827734