Systematic Oxidative Stress Indexes Associated with the Prognosis in Patients with T Lymphoblastic Lymphoma/Leukemia

• Published in: Oxidative medicine and cellular longevity Vol. 2022; pp. 1 - 11
• Main Authors: Ping, Liqin, Gao, Yan, He, Yanxia, Wang, Xiaoxiao, Bai, Bing, Huang, Cheng, Huang, Huiqiang
• Format: Journal Article
• Language: English
• Published: New York Hindawi 04.08.2022; Hindawi Limited
• Subjects: Antioxidants; Cancer therapies; Chemotherapy; Leukemia; Lymphocytes; Lymphoma; Medical prognosis; Oxidative stress; Patients; Pleural effusion; Regression analysis; Signal transduction; Software; Survival analysis; Ann Arbor Michigan; United States > US
• ISSN: 1942-0900; 1942-0994
• DOI: 10.1155/2022/2679154

Background. T lymphoblastic lymphoma/leukemia (T-LBL/ALL) is an aggressive malignant tumor with 5-year overall survival (OS) rate reached 80% after high-dose chemotherapy. Due to the relatively low incidence of T-LBL/ALL, only a few risk factors have been identified. The occurrence and prognosis of malignant tumors are closely related to oxidative stress, but the prognostic relationship between T-LBL/ALL and systematic oxidative stress indexes has not been reported yet. Methods. A total of 258 T-LBL/ALL patients were retrospectively analyzed. The relationship between systematic oxidative stress indexes, such as creatinine (CRE), gamma-glutamyl transpeptidase (γ-GGT), albumin (ALB), alkaline phosphatase (ALP), fibrinogen (FBG), C-reactive protein (CRP) and total bilirubin (TBIL), and survival of T-LBL/ALL patients, was analyzed. The weight of indexes was used to calculate the patients' oxidative stress risk score. The independent prognostic value of oxidative stress risk grouping (OSRG) was analyzed. Results. Higher CRE, CRP, and lower ALB were associated with poorer OS in T-LBL/ALL patients. The OSRG established by CRE, ALB, and CRP was an independent prognostic factor for OS of T-LBL/ALL patients. Patients in the high-risk group were more likely to be patients older than 14 years old and patients with superior vena cava obstruction syndrome (SVCS), pleural effusion, pericardial effusion, and mediastinal mass. Conclusion. For OS in T-LBL/ALL patients, OSRG was observed as an independent prognostic factor, which provided a new idea for accurate prognostic prediction.