Fatty Acid Binding Proteins—The Evolutionary Crossroads of Inflammatory and Metabolic Responses

Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins with the task of protecting a cell's delicate lipid balance. Yet they fail when faced with metabolic or inflammatory stress, turning the cytosol into an inhospitable environment with less than ideal outcome...

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Bibliographic Details
Published inThe Journal of nutrition Vol. 134; no. 9; pp. 2464S - 2468S
Main Authors Makowski, Liza, Hotamisligil, Gökhan S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2004
Subjects
animal models
Animals
Carrier Proteins - metabolism
enzyme activity
fatty acid binding protein (FABP)
Fatty Acid-Binding Proteins
Humans
inflammation
Inflammation - metabolism
insulin resistance
Lipid Metabolism
literature reviews
Metabolic Syndrome
Metabolic Syndrome - metabolism
mice
nutrition-genotype interaction
obesity
signal transduction
HSL
apo
PPAR
inflammation
Metabolic Syndrome
JNK
LXR
fatty acid binding protein (FABP)
IKK
FABP
insulin resistance
obesity
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Summary:Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins with the task of protecting a cell's delicate lipid balance. Yet they fail when faced with metabolic or inflammatory stress, turning the cytosol into an inhospitable environment with less than ideal outcomes. This review will focus on how FABPs direct lipid traffic and simultaneously control inflammatory and metabolic pathways under the pressures of the Metabolic Syndrome.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0022-3166
1541-6100
DOI:10.1093/jn/134.9.2464S