Macrophage Biology and Pathobiology in the Evolution of Immune Responses: A Functional Analysis

A number of general principles of macrophage biology and pathobiology are formulated to define the contribution of macrophages to the kinetics and sequencing of innate and adaptive immune responses more precisely. The application of these principles to modelling immune responses and to macrophage-ba...

Full description

Saved in:
Bibliographic Details
Published inPathobiology (Basel) Vol. 69; no. 4; pp. 179 - 211
Main Author Stoy, Nicholas
Format Journal Article
LanguageEnglish
Published Basel, Switzerland 01.01.2001
Subjects
Adaptation, Physiological - immunology
Animals
Evolution, Molecular
Humans
Immune System - pathology
Immune System - physiology
Immune Tolerance - immunology
Macrophages - immunology
Macrophages - pathology
Models, Biological
Review
Autoimmunity
Peripheral tolerance
Cytokines
NF-ĸB
Leishmania
Lipopolysaccharide
Inflammation
cAMP
Macrophage
Asthma
Online AccessGet full text

Cover

More Information
Summary:A number of general principles of macrophage biology and pathobiology are formulated to define the contribution of macrophages to the kinetics and sequencing of innate and adaptive immune responses more precisely. The application of these principles to modelling immune responses and to macrophage-based treatments of immune disorders is discussed. The concept of innate peripheral tolerance is developed. It is suggested that macrophage activation could be a primary determinant of nearly every aspect of immune responsiveness, both normal and abnormal, as might be predicted from the innate immune response to ‘danger’ being evolutionarily more primitive than the adaptive.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:1015-2008
1423-0291
DOI:10.1159/000055944