Sleep disorders and cognitive dysfunction in acromegaly
Purpose In the general population, sleep disorders are associated with an increased risk of cognitive impairment. The prevalence of sleep disorders, such as sleep apnea, in acromegalic patients is higher than in the general population, and they may have additional risk of cognitive impairment due to...
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Published in | Endocrine Vol. 66; no. 3; pp. 634 - 641 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.12.2019
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose
In the general population, sleep disorders are associated with an increased risk of cognitive impairment. The prevalence of sleep disorders, such as sleep apnea, in acromegalic patients is higher than in the general population, and they may have additional risk of cognitive impairment due to acromegaly treatment and comorbidities. We aim to study the relationship between sleep disturbances and cognitive dysfunction in a group of acromegalic patients.
Methods
We studied 67 consecutive acromegalic patients. We performed a neurocognitive assessment and patients completed the Acromegaly Quality of Life Questionnaire (AcroQoL), Epworth Sleepiness Scale, and Pittsburgh Sleep Quality Index.
Results
Of the 67 acromegaly patients in the study, 38.8% were male and median age at the neurological examination was 56 (IQR 48, 65). Approximately 6–10% of patients had impaired cognitive assessment, depending on the test. In linear regression models adjusted for age, sex, BMI, disease duration, and disease activity, poorer sleep quality was associated with lower global cognitive
z
-score (
B
= −0.03, 95% CI −0.06, −0.002). Daytime somnolence was associated with poorer physical AcroQoL sub-score (
B
= −0.04, 95% CI −0.08, −0.002). Sleep quality was associated with poorer overall AcroQoL (
B
= −0.03, 95% CI −0.05, −0.006), physical AcroQoL (
B
= −0.04, 95% CI −0.07, −0.005), psychological AcroQoL (
B
= −0.02, 95% CI −0.04, −0.001), and social AcroQoL (
B
= −0.02, 95% CI −0.04, −0.0009).
Conclusions
In acromegaly patients, we found robust evidence that poor sleep quality is associated with poorer quality of life, and some evidence that it is associated with poorer cognitive function. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1355-008X 1559-0100 1559-0100 |
DOI: | 10.1007/s12020-019-02061-1 |