Acanthomatous ameloblastoma with mucinous glandular differentiation in a dog

This report describes an atypical case of canine acanthomatous ameloblastoma (CAA) with mucinous glandular differentiation in a 12-year-old male Chihuahua with a right mandibular mass. Initially diagnosed as CAA by biopsy, computed tomography revealed bone lysis, prompting surgical excision. Histolo...

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Bibliographic Details
Published inJournal of Veterinary Medical Science Vol. 87; no. 2; pp. 194 - 197
Main Authors MINESHIGE, Takayuki, TAKAGI, Satoshi, SHIGA, Takanori, AIHARA, Naoyuki, YOSHIDA, Hiromitsu, KANAI, Eiichi, KAMIIE, Junichi
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2025
Japan Science and Technology Agency
The Japanese Society of Veterinary Science
Subjects
Ameloblastoma
Ameloblastoma - diagnosis
Ameloblastoma - pathology
Ameloblastoma - surgery
Ameloblastoma - veterinary
Animals
Biopsy
Bone mass
canine acanthomatous ameloblastoma
Cell proliferation
Computed tomography
Cytokeratin
Dog Diseases - diagnosis
Dog Diseases - pathology
Dog Diseases - surgery
Dogs
Immunohistochemistry
Immunohistochemistry - veterinary
Male
Malignancy
Mandibular Neoplasms - pathology
Mandibular Neoplasms - veterinary
mucinous glandular differentiation
odontogenic tumor
Pathology
Tumor cells
immunohistochemistry
canine acanthomatous ameloblastoma
mucinous glandular differentiation
odontogenic tumor
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Summary:This report describes an atypical case of canine acanthomatous ameloblastoma (CAA) with mucinous glandular differentiation in a 12-year-old male Chihuahua with a right mandibular mass. Initially diagnosed as CAA by biopsy, computed tomography revealed bone lysis, prompting surgical excision. Histological examination showed lobular growth with two distinct neoplastic cell populations: typical CAA-like cells and a minor glandular structure population. Mucinous glandular differentiation in CAA is undocumented in veterinary literature. Immunohistochemistry showed positivity for cytokeratin AE1/AE3 in all tumor cells, and cytokeratin CAM5.2 and Alcian blue staining confirmed glandular cells and mucin. A low mitotic and K-i67 proliferation index suggested low-grade malignancy. This rare case highlights the need for comprehensive histopathological and immunohistochemical analysis to distinguish CAA from other oral tumors.
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ISSN:0916-7250
1347-7439
1347-7439
DOI:10.1292/jvms.24-0374