Subclinical hepatic fibrosis is associated with coronary microvascular dysfunction by myocardial perfusion reserve index: a retrospective cohort study

• Published in: The international journal of cardiovascular imaging Vol. 38; no. 7; pp. 1579 - 1586
• Main Authors: Kwan, Alan C., Wei, Janet, Lee, Brian P., Luong, Eric, Salto, Gerran, Nguyen, Trevor-Trung, Botting, Patrick G., Liu, Yunxian, Ouyang, David, Ebinger, Joseph E., Li, Debiao, Noureddin, Mazen, Thomson, Louise, Berman, Daniel S., Merz, C. Noel Bairey, Cheng, Susan
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.07.2022; Springer Nature B.V
• Subjects: Abnormalities; Blood platelets; Cardiac Imaging; Cardiology; Cardiovascular disease; Cardiovascular diseases; Cohort analysis; Coronary artery disease; Ejection fraction; Fibrosis; Health risks; Heart; Heart diseases; Imaging; Laboratories; Liver; Liver diseases; Magnetic resonance imaging; Medicine; Medicine & Public Health; Metabolism; Microvasculature; Original Paper; Patients; Perfusion; Phenotypes; Radiology; Risk analysis; Risk factors; Hepatic fibrosis; Coronary perfusion; Cardiac MRI
• ISSN: 1875-8312; 1569-5794; 1875-8312; 1573-0743
• DOI: 10.1007/s10554-022-02546-7

The heart–liver axis is of growing importance. Previous studies have identified independent association of liver dysfunction and fibrosis with adverse cardiac outcomes, but mechanistic pathways remain uncertain. We sought to understand the relations between the degree of hepatic fibrosis identified by the Fibrosis-4 (Fib-4) risk score and comprehensive cardiac MRI (CMR) measures of subclinical cardiac disease. We conducted a retrospective single-center cohort study of patients between 2011 and 2021. We identified consecutive patients who underwent a comprehensive CMR imaging protocol including contrast enhanced with stress/rest perfusion, and lacked pre-existing cardiovascular disease or perfusion abnormalities on CMR. We examined the association of hepatic fibrosis, using the Fib-4 score, with subclinical cardiac disease on CMR while adjusting for cardiometabolic traits. Given known associations of hepatic disease and coronary microvascular dysfunction, we prioritized analyses with the myocardial perfusion reserve index (MPRI), a marker of coronary microvascular function. Of the 66 patients in our study cohort, 54 were female (81%) and the mean age was 53.7 ± 15.3 years. We found that higher Fib-4 was associated with reduction in the MPRI (β [SE] − 1.12 [0.46], P = 0.02), after adjusting for cardiometabolic risk factors. Importantly, Fib-4 was not significantly associated with any other CMR phenotypes including measures of cardiac remodeling, inflammation, fibrosis, or dysfunction. We found evidence that hepatic fibrosis associated with coronary microvascular dysfunction, in the absence of overt associations with any other subclinical cardiac disease measures. These findings highlight a potentially important precursor pathway leading to development of subsequent heart–liver disease.