Arsenical C-Glucoside Derivatives with Promising Antitumor Activity

C‐Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized by avoiding protection‐deprotection steps. While compound 1, bearing an AsV atom, did not show any significant biological activity, compound 2, in which the glucose moiety is linked to t...

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Bibliographic Details
Published inEuropean journal of organic chemistry Vol. 2015; no. 21; pp. 4620 - 4623
Main Authors D'Orazio, Giuseppe, Parisi, Gelsomina, Policano, Claudia, Mechelli, Rosella, Codacci Pisanelli, Giovanni, Pitaro, Michele, Ristori, Giovanni, Salvetti, Marco, Nicotra, Francesco, La Ferla, Barbara
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.07.2015
WILEY‐VCH Verlag
Wiley
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Summary:C‐Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized by avoiding protection‐deprotection steps. While compound 1, bearing an AsV atom, did not show any significant biological activity, compound 2, in which the glucose moiety is linked to the arsenic atom as dithioarsenical (AsIII), showed promising antiproliferative activity on a cell line of neuroblastoma (SK‐N‐BE). C‐Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized. The C‐glucoside conjugated to the phenyldithioarsolan group, showed promising antiproliferative activity on human neuroblastoma cells (SK‐N‐BE).
Bibliography:ark:/67375/WNG-4G2TNV99-7
ArticleID:EJOC201500529
istex:0FF29F313FF4CDB1AAF8DD0BC3A1F6A138EAF448
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201500529