Arsenical C-Glucoside Derivatives with Promising Antitumor Activity

C‐Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized by avoiding protection‐deprotection steps. While compound 1, bearing an AsV atom, did not show any significant biological activity, compound 2, in which the glucose moiety is linked to t...

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Published inEuropean journal of organic chemistry Vol. 2015; no. 21; pp. 4620 - 4623
Main Authors D'Orazio, Giuseppe, Parisi, Gelsomina, Policano, Claudia, Mechelli, Rosella, Codacci Pisanelli, Giovanni, Pitaro, Michele, Ristori, Giovanni, Salvetti, Marco, Nicotra, Francesco, La Ferla, Barbara
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.07.2015
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Antiproliferation
Arsenic
Arsenic-glyco derivatives
C-Glucosides
Chemistry
Chemistry, Organic
GLUT transporter
Physical Sciences
Science & Technology
Antiproliferation
GLUT transporter
C-Glucosides
Arsenic
Arsenic-glyco derivatives
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Summary:C‐Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized by avoiding protection‐deprotection steps. While compound 1, bearing an AsV atom, did not show any significant biological activity, compound 2, in which the glucose moiety is linked to the arsenic atom as dithioarsenical (AsIII), showed promising antiproliferative activity on a cell line of neuroblastoma (SK‐N‐BE). C‐Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized. The C‐glucoside conjugated to the phenyldithioarsolan group, showed promising antiproliferative activity on human neuroblastoma cells (SK‐N‐BE).
Bibliography:ark:/67375/WNG-4G2TNV99-7
ArticleID:EJOC201500529
istex:0FF29F313FF4CDB1AAF8DD0BC3A1F6A138EAF448
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201500529