Effects of arginine vasopressin on the transcriptome of prefrontal cortex in autistic rat model

Our previous studies have also demonstrated that AVP can significantly improve social interaction disorders and stereotypical behaviours in rats with VPA‐induced autism model. To further explore the mechanisms of action of AVP, we compared the PFC transcriptome changes before and after AVP treatment...

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Published inJournal of cellular and molecular medicine Vol. 26; no. 21; pp. 5493 - 5505
Main Authors Zhou, Bo, Yan, Xuehui, Yang, Liu, Zheng, Xiaoli, Chen, Yunhua, Liu, Yibu, Ren, Yibing, Peng, Jingang, Zhang, Yi, Huang, Jiayu, Tang, Lei, Wen, Min
Format Journal Article
LanguageEnglish
Published Chichester John Wiley & Sons, Inc 01.11.2022
John Wiley and Sons Inc
Subjects
Animal cognition
arginine vasopressin
Argipressin
Autism
autism spectrum disorder
Behavior
Bioinformatics
Dysplasia
Embryos
Gene expression
Genomes
Myelin
neurodevelopmental
oligodendrocyte
Ontology
Original
Prefrontal cortex
Quality control
Rodents
Signal transduction
Statistical significance
synapse
Synaptogenesis
Transcriptomes
Valproic acid
Vasopressin
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Summary:Our previous studies have also demonstrated that AVP can significantly improve social interaction disorders and stereotypical behaviours in rats with VPA‐induced autism model. To further explore the mechanisms of action of AVP, we compared the PFC transcriptome changes before and after AVP treatment in VPA‐induced autism rat model. The autism model was induced by intraperitoneally injected with VPA at embryonic day 12.5 and randomly assigned to two groups: the VPA‐induced autism model group and the AVP treatment group. The AVP treatment group were treated with intranasal AVP at postnatal day 21 and for 3 weeks. The gene expression levels and function changes on the prefrontal cortex were measured by RNA‐seq and bioinformatics analysis at PND42 and the mRNA expression levels of synaptic and myelin development related genes were validated by qPCR. Our results confirmed that AVP could significantly improve synaptic and axon dysplasia and promote oligodendrocyte development in the prefrontal cortex in VPA‐induced autism models by regulating multiple signalling pathways.
Bibliography:Bo Zhou, Xuehui Yan and Liu Yang contributed equally to this study.
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ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.17578