Candida parapsilosis keratitis treated successfully with topical and oral fluconazole

A 73-year-old male patient presented with ocular pain, redness, and blurred vision in the left eye, which had been ongoing for more than 2 months. An oval-shaped paracentral corneal ulcer with stromal infiltration and a mild anterior chamber reaction were found. Despite treatment with empiric antibi...

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Bibliographic Details
Published inTaiwan journal of ophthalmology Vol. 6; no. 3; pp. 155 - 157
Main Authors Li, Pei-Hsuan, Chen, Chun-Chen, Liou, Shiow-Wen
Format Journal Article
LanguageEnglish
Published India Elsevier B.V 01.07.2016
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Subjects
Candida parapsilosis
Case Report
Fluconazole
fungal keratitis
Type 2 diabetes
fluconazole
fungal keratitis
Candida parapsilosis
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Summary:A 73-year-old male patient presented with ocular pain, redness, and blurred vision in the left eye, which had been ongoing for more than 2 months. An oval-shaped paracentral corneal ulcer with stromal infiltration and a mild anterior chamber reaction were found. Despite treatment with empiric antibiotics, the lesion progressed and corneal thinning in the middle area was noted. The culture yielded Candida parapsilosis. We therefore prescribed topical 0.2% fluconazole (FCZ) in combination with oral FCZ as an antifungal treatment, following which the stromal infiltration gradually subsided. Complete epithelialization was noted on the 8th day after initiating FCZ therapy. There was no recurrent disease in the subsequent 2 years. Our case demonstrates that topical FCZ 0.2% in combination with oral FCZ can successfully treat C. parapsilosis keratitis and result in a good visual outcome.
Bibliography:ObjectType-Case Study-2
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ISSN:2211-5056
2211-5072
DOI:10.1016/j.tjo.2016.04.007