Two cases of multiple eccrine spiradenoma with linear or localized formation

• Published in: Journal of dermatology Vol. 31; no. 7; p. 564
• Main Authors: Yoshida, Aki, Sato, Toshiki, Sugawara, Yuki, Matsuta, Mayumi, Akasaka, Toshihide
• Format: Journal Article
• Language: English
• Published: England 01.07.2004
• Subjects: Adenoma, Sweat Gland - pathology; Adult; Biopsy, Needle; Eccrine Glands - pathology; Female; Follow-Up Studies; Humans; Immunohistochemistry; Middle Aged; Neoplasm Staging; Rare Diseases; Risk Assessment; Sweat Gland Neoplasms - pathology
• ISSN: 0385-2407; 1346-8138
• DOI: 10.1111/j.1346-8138.2004.tb00556.x

We report two rare cases of recurrent, multiple eccrine spiradenoma. Both cases presented with extensive lesions comprised of multiple red papules of various sizes and a soft blue-red nodule. The first case was a 30-year-old woman. Her lesions followed a linear arrangement on her chin, and extended down the right side of the neck with spontaneous pain. The second case was a 57-year-old woman with tumors in a localized group on the left occipital region without pain. A search of the literature revealed only 15 reported cases of linear/zosteriform/nevoid multiple eccrine spiradenoma. Both cases were treated by surgical excision. Most of the red papules displayed typical histological features including two cell types: large clear cells with low-density cytoplasm; and small dark cells with high-density cytoplasm. The large soft tumors exhibited a variable histological appearance. In the first case, the cystic tumors displayed an homogeneous structure comprised of eosinophilic material. In the second case, the cystic tumors included abundant interstitial tissue.